Enzymatic and Chemo–catalytic Redox Deracemization: Recent Progress

The precise synthesis of chiral small molecules is a core research area in chemical science. Deracemization, an appealing technology that converts racemate to its single enantiomer with the same constitution in theoretical 100 % yield, appears as a straightforward and efficient strategy in asymmetric synthesis. A cascading redox sequence was the most employed approach to drive deracemization through destroy and recreate the stereocenter in a given molecule. This review mainly focuses on the progress of redox deracemization driven by respective biocatalysis and chemo–catalysis. In particular, each section will be subdivided according to the action modes, the respective substrate classes and perspectives on future development.