研究论文
Efficient Preparation of the Key Intermediate in Corey's Tamiflu Synthesis
Zhangyong Hong, Qi Cui, Jiannan Peng, Huan Hu, Zeming Chen
Nankai University
来源Chinese Journal of Chemistry
年份2010
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摘要与影响
摘要 · 完整
A very efficient two‐step synthesis was developed to prepare the key intermediate in Corey's Tamiflu synthesis. DBU (1,8‐diazabicyclo[5.4.0] undec‐7‐ene) was used as a multifunctional catalyst for a series of reactions in a one pot procedure. The new synthesis was featured by the good availability of the starting material and the ease of the synthetic steps. This method might be practical for large scale preparations.
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5
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0.67
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同类平均 = 1
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前 29%
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学术脉络
学科主题
化学Synthetic Organic Chemistry Methods
Microbial Natural Products and Biosynthesis · Asymmetric Synthesis and Catalysis
参考文献 22
Synthetic Strategies for Oseltamivir Phosphate
被引 121Masakatsu Shibasaki, Motomu Kanai · European Journal of Organic Chemistry · 2008
A Short Enantioselective Pathway for the Synthesis of the Anti-Influenza Neuramidase Inhibitor Oseltamivir from 1,3-Butadiene and Acrylic Acid
被引 267Yeung, Sungwoo Hong, E. J. Corey · Journal of the American Chemical Society · 2006
First Synthesis of a Bidesmosidic Triterpene Saponin by a Highly Efficient Procedure
被引 89Biao Yu, Jianming Xie, Shaojiang Deng · Journal of the American Chemical Society · 1999
此处列出前 3 条
引用本文 5
A novel and high-yielding asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from (−)-shikimic acid
被引 25Liang‐Deng Nie, Wei Ding, Xiao‐Xin Shi · Tetrahedron Asymmetry · 2012
A novel azide-free asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from Roche’s epoxide
被引 20Liang‐Deng Nie, Fei-Feng Wang, Wei Ding · Tetrahedron Asymmetry · 2013
Novel asymmetric synthesis of oseltamivir phosphate (Tamiflu) from (−)-shikimic acid via cyclic sulfite intermediates
被引 19Liang‐Deng Nie, Xiao‐Xin Shi, Na Quan · Tetrahedron Asymmetry · 2011
按被引量排序，此处列出前 3 条