Synthesis of Plasmin‐Loaded Fe3O4@CaCO3 Nanoparticles: Towards Next‐Generation Thrombolytic Drugs

A major obstacle in the development of the next‐generation of thrombolytic drugs has been the fact that plasmin – a serine protease that dissolves fibrin in blood clots – despite being the only enzyme suitable for the clot cleavage, is still not used in practice due to its rapid inactivation. Here we point to a potential solution to this problem by developing a magnetically controlled system for targeted delivery and recrystallization‐driven release of plasmin showing therapeutic potential.