Cover Feature: Extending Cofactor‐Tethered Nanomachines to Complex Multienzyme Redox Cascades in Continuous Flow (ChemSusChem 17/2026)
Zinnia Dsouza, Jan‐Simon Jeshua Friedrichs, Okke Melse, Gerhard Schenk, Volker Sieber
Technical University of Munich The University of Queensland
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摘要与影响
The Cover Feature places cofactor-tethered fused-enzyme nanomachines in the spotlight, connecting molecular-scale design with industrial-scale biocatalysis. The continuous-flow reactor represents the reliance of conventional redox enzyme cascades on freely diffusing, valuable nicotinamide cofactors, whereas the nanomachine strategy retains and recycles these cofactors to support cofactor-autonomous operation, advancing sustainable biomanufacturing. More information can be found in the Research Article by V. Sieber and co-workers (DOI: 10.1002/cssc.70914).
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生物医学Enzyme Catalysis and Immobilization
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