研究论文

Boosting split-crRNA CRISPR/Cas12a activity by 3′-end extension of DNA activator for direct microRNA sensing

Lin Hou, Fangqi Ruan, Kai-Ren Zhao, Baoxin Li

Shaanxi Normal University　Xijing Hospital　Air Force Medical University

来源Analytica Chimica Acta

年份2025

DOI10.1016/j.aca.2025.344841

原文https://doi.org/10.1016/j.aca.2025.344841

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逐年被引趋势

420

426

关键指标

被引次数 · OpenAlex

1.58

领域内被引倍数
同类平均 = 1

前 16%

引用位次
同领域 · 同年份 · 同类型

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学术脉络

学科主题

生物医学

CRISPR and Genetic Engineering

MicroRNA in disease regulation · RNA regulation and disease

参考文献 33

Real-time quantification of microRNAs by stem-loop RT-PCR

C. Chen · Nucleic Acids Research · 2005

被引 5,027

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington · Science · 2018

被引 4,500

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

Shiyuan Li, Qiuxiang Cheng, Jia-Kun Liu · Cell Research · 2018

被引 1,157

此处列出前 3 条

引用本文 4

A Review of Activator Strand Engineering Strategies for Smart CRISPR/Cas12a Diagnostics

Xin-Yue Wang, Yi-Xiang Wang, Qing-Nan Li · ACS Sensors · 2026

被引 1

Rapid and simple microwave-assisted DNA immobilization for sensitive label-free electrochemical biosensor with cascade enzymatic recycling cleavage amplification

Xudong Zhou, Mingrui Zhang, Ying Jiang · Microchemical Journal · 2026

被引 0

Synergistic chemical modifications and structural tuning to overcome natural gRNA limitations for next-generation CRISPR biosensors

Guangrong Zou, Xiaojing Liu, YJ Li · TrAC Trends in Analytical Chemistry · 2026