研究论文

Discovery of farnesoid X receptor antagonists from Salvia miltiorrhiza based on virtual screening and activity verification

Jiaojiao Tu, Wa Cheng, Zhenghu Ban, Jiayi Ning, Xiangduan Tan

Guilin Medical University

来源Bioorganic & Medicinal Chemistry Letters

年份2025

DOI10.1016/j.bmcl.2025.130222

原文https://doi.org/10.1016/j.bmcl.2025.130222

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逐年被引趋势

210

226

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被引次数 · OpenAlex

2.04

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同类平均 = 1

前 16%

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学术脉络

学科主题

生物医学

Pharmacological Effects of Natural Compounds

Medicinal Plant Pharmacodynamics Research · Traditional Chinese Medicine Analysis

参考文献 58

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

Michael M. Mysinger, Michael Carchia, John J. Irwin · Journal of Medicinal Chemistry · 2012

被引 2,466

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

Wenyu Wu, Yiping Wang · Acta Pharmacologica Sinica · 2012

被引 123

Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump

Jisong Cui, Li Huang, Annie Zhao · Journal of Biological Chemistry · 2003

被引 242

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被引 0

Dysregulation of the bile acid signaling network in non-alcoholic fatty liver disease: Mechanisms and a new paradigm of precision network pharmacology

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