研究论文

The brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone mitigates NLRP3 inflammasome activation and GSDMD-mediated pyroptosis and enhances the negative regulatory pathways of pyroptosis in microglia

Mehmet Erdem, Şeniz Erdem, Süleyman Caner Karahan, Ahmet Alver, Soner Karabulut, Gökhan Yıldız

Turgut Özal University　Karadeniz Technical University

来源Journal of Neuroimmunology

年份2025

DOI10.1016/j.jneuroim.2025.578684

原文https://doi.org/10.1016/j.jneuroim.2025.578684

内容与影响

摘要 · 节选

暂未获取摘要。可打开原文或 PDF，后续可基于全文生成更完整的速读。

逐年被引趋势

320

326

关键指标

被引次数 · OpenAlex

2.43

领域内被引倍数
同类平均 = 1

前 11%

引用位次
同领域 · 同年份 · 同类型

参考文献

Google Scholar 与 OpenAlex 的被引统计范围不同，数值存在差异属正常。

AI 辅助阅读

依据：文献信息

论文问答

依据：文献信息 · 当前未解析全文

回答优先基于摘要、文献信息与可获取全文；依据不足时会明确说明。

依据：当前详情页数据

学术脉络

学科主题

生物医学

Inflammasome and immune disorders

Adenosine and Purinergic Signaling · Neuroinflammation and Neurodegeneration Mechanisms

参考文献 64

Activation of TrkB by 7,8-Dihydroxyflavone Prevents Fear Memory Defects and Facilitates Amygdalar Synaptic Plasticity in Aging

Yan Zeng, Ya-kun Liu, Mianyun Wu · Journal of Alzheimer s Disease · 2012

被引 72

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

Zhentao Zhang, Xia Liu, Jason P. Schroeder · Neuropsychopharmacology · 2013

被引 241

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Sung‐Wuk Jang, Xia Liu, Manuel Yepes · Proceedings of the National Academy of Sciences · 2010

被引 679

此处列出前 3 条

施引文献 5

Dual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells

Ömer Faruk Kalkan, Şeniz Erdem, Mehmet Erdem · Neuropeptides · 2025

被引 1

Nitidine chloride alleviates inflammation and pyroptosis by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway in macrophages and murine models

Yi Zhou, Zhaodi Wu, Dandan Zheng · Journal of Ethnopharmacology · 2026

被引 1

The Role of Neuroinflammation in the Development of Seizure Activity and Autonomic Disorders in Patients with Epilepsy

G. V. Selitsky, N. D. Sorokina, P. R. Kamchatnov · Neuroscience and Behavioral Physiology · 2026

被引 0

按被引量排序，此处列出前 3 条

研究论文

The brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone mitigates NLRP3 inflammasome activation and GSDMD-mediated pyroptosis and enhances the negative regulatory pathways of pyroptosis in microglia

Mehmet Erdem, Şeniz Erdem, Süleyman Caner Karahan, Ahmet Alver, Soner Karabulut, Gökhan Yıldız

Turgut Özal University　Karadeniz Technical University

来源Journal of Neuroimmunology

年份2025

DOI10.1016/j.jneuroim.2025.578684

原文https://doi.org/10.1016/j.jneuroim.2025.578684

内容与影响

摘要 · 节选

暂未获取摘要。可打开原文或 PDF，后续可基于全文生成更完整的速读。

逐年被引趋势

320

326

关键指标

被引次数 · OpenAlex

2.43

领域内被引倍数
同类平均 = 1

前 11%

引用位次
同领域 · 同年份 · 同类型

参考文献

Google Scholar 与 OpenAlex 的被引统计范围不同，数值存在差异属正常。

AI 辅助阅读

依据：文献信息

论文问答

依据：文献信息 · 当前未解析全文

回答优先基于摘要、文献信息与可获取全文；依据不足时会明确说明。

依据：当前详情页数据

学术脉络

学科主题

生物医学

Inflammasome and immune disorders

Adenosine and Purinergic Signaling · Neuroinflammation and Neurodegeneration Mechanisms

参考文献 64

Activation of TrkB by 7,8-Dihydroxyflavone Prevents Fear Memory Defects and Facilitates Amygdalar Synaptic Plasticity in Aging

Yan Zeng, Ya-kun Liu, Mianyun Wu · Journal of Alzheimer s Disease · 2012

被引 72

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

Zhentao Zhang, Xia Liu, Jason P. Schroeder · Neuropsychopharmacology · 2013

被引 241

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Sung‐Wuk Jang, Xia Liu, Manuel Yepes · Proceedings of the National Academy of Sciences · 2010

被引 679

此处列出前 3 条

施引文献 5

Ömer Faruk Kalkan, Şeniz Erdem, Mehmet Erdem · Neuropeptides · 2025

被引 1

Nitidine chloride alleviates inflammation and pyroptosis by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway in macrophages and murine models

Yi Zhou, Zhaodi Wu, Dandan Zheng · Journal of Ethnopharmacology · 2026

被引 1

The Role of Neuroinflammation in the Development of Seizure Activity and Autonomic Disorders in Patients with Epilepsy

G. V. Selitsky, N. D. Sorokina, P. R. Kamchatnov · Neuroscience and Behavioral Physiology · 2026

被引 0

按被引量排序，此处列出前 3 条