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Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?

Wojciech Madej, A. van Caam, E. Blaney Davidson, Pieter Buma, P.M. van der Kraan

Radboud University Nijmegen　Radboud University Medical Center　Radboud Institute for Molecular Life Sciences

来源Osteoarthritis and Cartilage

年份2016

DOI10.1016/j.joca.2016.05.018

原文https://doi.org/10.1016/j.joca.2016.05.018

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生物医学

Osteoarthritis Treatment and Mechanisms

TGF-β signaling in diseases · Connective Tissue Growth Factor Research

参考文献 44

Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells

ETH Zürich, Cartilage Engineering and Regeneration, Gloriastrasse 35, ETZ F84, 8092 Zürich, Switzerland, Deborah Studer, Carola Millán · European Cells and Materials · 2012

被引 199

Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage

Wojciech Madej, A. van Caam, E.N. Blaney Davidson · Osteoarthritis and Cartilage · 2015

被引 58

Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction

S J Kim, K T Jeang, Adam B. Glick · Journal of Biological Chemistry · 1989

被引 246

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引用本文 40

TGFβ/BMP Signaling Pathway in Cartilage Homeostasis

Nathalie G. M. Thielen, P.M. van der Kraan, A. van Caam · Cells · 2019

被引 256

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

P.M. van der Kraan · Nature Reviews Rheumatology · 2017

被引 231