研究论文开放获取

Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers

Chien-Chu Lin, Yani Zhao, Caroline A. Foley, Aspen T. Hawkins, Lindsey I. James, Stephen V. Frye, Robert K. McGinty

University of North Carolina at Chapel Hill

来源Molecular Cell

年份2025

DOI10.1016/j.molcel.2025.06.025

原文https://doi.org/10.1016/j.molcel.2025.06.025

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逐年被引趋势

530

526

关键指标

被引次数 · OpenAlex

1.81

领域内被引倍数
同类平均 = 1

前 15%

引用位次
同领域 · 同年份 · 同类型

参考文献

Google Scholar 与 OpenAlex 的被引统计范围不同，数值存在差异属正常。

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依据：文献信息

论文问答

当前基于文献信息回答

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学术脉络

学科主题

生物医学

Epigenetics and DNA Methylation

Cancer-related gene regulation · Histone Deacetylase Inhibitors Research

参考文献 67

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

Qingtian Li, Jia Zou, Mingjun Wang · Nature Communications · 2014

被引 157

Structure–Activity Analysis of Semisynthetic Nucleosomes: Mechanistic Insights into the Stimulation of Dot1L by Ubiquitylated Histone H2B

Robert K. McGinty, Maja Köhn, Champak Chatterjee · ACS Chemical Biology · 2009

被引 122

Human UTY(KDM6C) Is a Male-specific Nϵ-Methyl Lysyl Demethylase

Louise J. Walport, Richard J. Hopkinson, M. Vollmar · Journal of Biological Chemistry · 2014

被引 221

此处列出前 3 条

引用本文 5

Histone modifications across cancers: mechanisms, therapy and clinical translation

Pengde Lu, Yau-Tuen Chan, Chun-Fung Kwok · Molecular Cancer · 2026

被引 2

Alpha-Ketoglutarate Drives an Osteogenic and Extracellular Matrix Gene Program in Periodontal Ligament Fibroblasts via Selective Reduction of H3K27me3

Ryu Hasegawa, Shigeki Suzuki, Rahmad Rifqi Fahreza · Biology · 2026

被引 1

DEK recruits KAT6A regulate H3K27ac/c-myc axis to drive enhanced glycolysis and immune escape in gastric cancer

Liu W, Zhiran Yang, Bingyu Wang · Free Radical Biology and Medicine · 2026

被引 0

按被引量排序，此处列出前 3 条

研究论文开放获取

Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers

Chien-Chu Lin, Yani Zhao, Caroline A. Foley, Aspen T. Hawkins, Lindsey I. James, Stephen V. Frye, Robert K. McGinty

University of North Carolina at Chapel Hill

来源Molecular Cell

年份2025

DOI10.1016/j.molcel.2025.06.025

原文https://doi.org/10.1016/j.molcel.2025.06.025

阅读操作

确认中

在文库中上传 PDF 后可生成中文音频讲解。

摘要与影响

摘要 · 节选

暂未获取摘要。可打开原文或 PDF，后续可基于全文生成更完整的速读。

逐年被引趋势

530

526

关键指标

被引次数 · OpenAlex

1.81

领域内被引倍数
同类平均 = 1

前 15%

引用位次
同领域 · 同年份 · 同类型

参考文献

Google Scholar 与 OpenAlex 的被引统计范围不同，数值存在差异属正常。

AI 辅助阅读

依据：文献信息

论文问答

当前基于文献信息回答

可就本文提问；依据不足时会说明。

学术脉络

学科主题

生物医学

Epigenetics and DNA Methylation

Cancer-related gene regulation · Histone Deacetylase Inhibitors Research

参考文献 67

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

Qingtian Li, Jia Zou, Mingjun Wang · Nature Communications · 2014

被引 157

Structure–Activity Analysis of Semisynthetic Nucleosomes: Mechanistic Insights into the Stimulation of Dot1L by Ubiquitylated Histone H2B

Robert K. McGinty, Maja Köhn, Champak Chatterjee · ACS Chemical Biology · 2009

被引 122

Human UTY(KDM6C) Is a Male-specific Nϵ-Methyl Lysyl Demethylase

Louise J. Walport, Richard J. Hopkinson, M. Vollmar · Journal of Biological Chemistry · 2014

被引 221

此处列出前 3 条

引用本文 5

Histone modifications across cancers: mechanisms, therapy and clinical translation

Pengde Lu, Yau-Tuen Chan, Chun-Fung Kwok · Molecular Cancer · 2026

被引 2

Alpha-Ketoglutarate Drives an Osteogenic and Extracellular Matrix Gene Program in Periodontal Ligament Fibroblasts via Selective Reduction of H3K27me3

Ryu Hasegawa, Shigeki Suzuki, Rahmad Rifqi Fahreza · Biology · 2026

被引 1

DEK recruits KAT6A regulate H3K27ac/c-myc axis to drive enhanced glycolysis and immune escape in gastric cancer

Liu W, Zhiran Yang, Bingyu Wang · Free Radical Biology and Medicine · 2026

被引 0

按被引量排序，此处列出前 3 条