Dual-role deep eutectic solvent engineering in HOF-101 supported molecularly imprinted polymers for enhanced myricetin adsorption

The efficient capture of myricetin is often challenged by its instability in alkaline environments, which contradicts the alkaline conditions required for traditional boronate affinity materials. To address this, a dual-recognition molecularly imprinted polymer (DMIP) supported on HOF-101 was developed using a deep eutectic solvent (DES)-driven strategy. A dual DES system was employed to achieve synergistic recognition: ternary DES 1 acts as a functional monomer combining boronate affinity and hydrogen bonding, while binary DES 2 serves as a green solvent and porogen. Crucially, the ethylene glycol in DES 2 facilitates “teamed boronate affinity” via B–O coordination, significantly lowering the p K a of boronic acid groups. This mechanism enables efficient specific recognition at pH 6.0, effectively overcoming the limitation of decreased affinity under weakly acidic conditions. The optimized BA-DES/DMIPs exhibited rapid equilibrium (20 min), a high Langmuir maximum adsorption capacity (45.016 mg/g), and excellent stability over five cycles. Furthermore, the material demonstrated superior selectivity against structural analogs and achieved satisfactory recovery rates (99.80%–101.67%) in grape juice, confirming its potential for green and efficient separation in complex matrices.