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A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation
Hongqing Zhang, Zherui Zhang, Cheng‐Lin Deng, Zhiming Yuan, Bo Zhang
Chinese Academy of Sciences Wuhan Institute of Virology University of Chinese Academy of Sciences
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摘要与影响
摘要 · 完整
• The recombinant VSV-EBOV is highly lethal to IFNα/β/γ R-/- mice. • The infected mice exhibit hyperviremia and distinct splenohepatic lesions. • Venezuelan equine encephalitis virus-based replicon particle vaccine can protect all IFNα/β/γ R -/- mice against VSV-EBOV challenge. • This surrogate model can be used for EBOV vaccine evaluation in BSL-2 laboratory.
逐年被引趋势
210
24
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226
关键指标
4
被引次数 · OpenAlex
1.36
领域内被引倍数
同类平均 = 1
同类平均 = 1
前 21%
引用位次
同领域 · 同年份 · 同类型
同领域 · 同年份 · 同类型
15
参考文献
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学术脉络
学科主题
生物医学Viral Infections and Outbreaks Research
Poxvirus research and outbreaks · Viral Infections and Vectors
参考文献 15
Modeling the Disease Course ofZaire ebolavirusInfection in the Outbred Guinea Pig
被引 47Robert W. Cross, Karla A. Fenton, Joan B. Geisbert · The Journal of Infectious Diseases · 2015
Recombinant RNA replicons derived from attenuated Venezuelan equine encephalitis virus protect guinea pigs and mice from Ebola hemorrhagic fever virus
被引 199Peter Pushko, Mike Bray, George V. Ludwig · Vaccine · 2000
Disease modeling for Ebola and Marburg viruses
被引 181Dennis A. Bente, Jason Gren, James E. Strong · Disease Models & Mechanisms · 2009
此处列出前 3 条
引用本文 4
Rational design of self-amplifying virus-like vesicles with Ebola virus glycoprotein as vaccines
被引 6Hongqing Zhang, Yanan Zhang, Cheng‐Lin Deng · Molecular Therapy · 2024
Engineered bispecific antibodies achieve broad and potent protection against multiple ebolavirus species
被引 4Jin Zhou, Baoyue Zhang, Yanfeng Yao · Emerging Microbes & Infections · 2026
Recombinant live attenuated measles virus-based vaccines inducing comprehensive protection against Ebola and Marburg viruses
被引 3Junhui Zhou, Xinghai Zhang, Yanfeng Yao · Molecular Therapy · 2025
按被引量排序，此处列出前 3 条