研究论文
Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study
Kenneth Cusi, Naim Alkhouri, Stephen A. Harrison, Pascale Fouqueray, David E. Moller, Sophie Hallakou‐Bozec, Sébastien Bolze, Jean‐Marie Grouin 等 11 位
University of Florida Malcom Randall VA Medical Center Arizona Liver Health Pinnacle Clinical Research
来源The Lancet. Gastroenterology & hepatology
年份2021
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学术脉络
学科主题
生物医学Metabolism, Diabetes, and Cancer
Liver Disease Diagnosis and Treatment · Diet and metabolism studies
参考文献 37
Liver fat quantification using a multi‐step adaptive fitting approach with multi‐echo GRE imaging
被引 216Xiaodong Zhong, Dominik Nickel, Stephan Kannengießer · Magnetic Resonance in Medicine · 2013
Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes
被引 156Pablo Aschner, H. L. Katzeff, Hongquan Guo · Diabetes Obesity and Metabolism · 2009
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
被引 212Marie‐Soleil Gauthier, Elena L O’Brien, Sherman Bigornia · Biochemical and Biophysical Research Communications · 2010
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引用本文 76
New insights into activation and function of the AMPK
被引 1,018Gregory R. Steinberg, D. Grahame Hardie · Nature Reviews Molecular Cell Biology · 2022
Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms
被引 199Gregory R. Steinberg, Celina M Valvano, William De Nardo · Journal of Hepatology · 2025
Expert Panel Recommendations: Practical Clinical Applications for Initiating and Monitoring Resmetirom in Patients With MASH/NASH and Moderate to Noncirrhotic Advanced Fibrosis
被引 154Mazen Noureddin, Michael Charlton, Stephen A. Harrison · Clinical Gastroenterology and Hepatology · 2024
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