A Double-Shell Hollow Hf-MOF-Driven Electrochemiluminescence Strategy for the Detection of miRNA-7

Se Schottky junction array was prepared to provide a uniform and stable electromagnetic field enhancement. Benefiting from the surface plasmonic coupling effect, the luminescence intensity of DSH Hf-MOF was enhanced 7.05 times. The DSH Hf-MOF-driven electrochemiluminescence (ECL) sensor was used for the detection of miRNA-7 with a range from 0.5 fM to 1 nM and a low detection limit of 0.15 fM. More importantly, this biosensor can effectively distinguish between glioma tumor tissues and adjacent paracancerous tissues, demonstrating clear application value in clinical pathological differentiation.