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Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers
Victoria C. Yan, Cong-Dat Pham, Elliot Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha 等 21 位
The University of Texas MD Anderson Cancer Center
来源Journal of Medicinal Chemistry
年份2022
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摘要 · 完整
. The activity of select prodrugs was also probed using the NCI-60 cell line screen, supporting its use to examine the relationship between prodrugs and cell line-dependent bioactivation.
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学术脉络
学科主题
化学Organophosphorus compounds synthesis
Cancer, Hypoxia, and Metabolism · Biochemical and Molecular Research
参考文献 75
Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs
被引 125Mn Arimilli, C. U. KIM, Joseph P. Dougherty · Antiviral chemistry & chemotherapy · 1997
Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs
被引 612Ugo Pradère, Ethel C. Garnier‐Amblard, Steven J. Coats · Chemical Reviews · 2014
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.
被引 1,139Leo E. Gerweck, K Seetharaman · PubMed · 1996
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引用本文 15
Synthetic Methods for Azaheterocyclic Phosphonates and Their Biological Activity: An Update 2004–2024
被引 55Martha C. Mayorquín‐Torres, Andreas Simoens, Eli Bonneure · Chemical Reviews · 2024
Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers
被引 21Jiaojiao Ni, Yihui Huang, Chaoqun Li · Molecular Therapy — Oncolytics · 2023
Enolase inhibitors as therapeutic leads for Naegleria fowleri infection
被引 18Jillian E. Milanes, Victoria C. Yan, Cong-Dat Pham · PLoS Pathogens · 2024
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