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A Λ -Ir( iii )-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1
Lu Zhu, Xingyun Wang, Xingyun Wang, Tian Tian, Yanyan Chen, Wenjing Du, Wei Wei, Jing Zhao 等 11 位
Nanjing University
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摘要与影响
摘要 · 完整
-IrPPQ achieved precise regulation of ferroptosis in pancreatic cancer cells. This work provides new insights into the design of chiral ferroptosis-inducing metallodrugs for future pancreatic cancer therapy.
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17
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4.38
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学术脉络
学科主题
生物医学Ferroptosis and cancer prognosis
Metal complexes synthesis and properties · Ferrocene Chemistry and Applications
参考文献 46
Probing Chiral Recognition of Enzyme Active Sites with Octahedral Iridium(III) Propeller Complexes
被引 23Peter Göbel, Florian Ritterbusch, Melanie Helms · European Journal of Inorganic Chemistry · 2015
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
被引 18,419Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht · Cell · 2012
Multidrug resistance in cancer: role of ATP–dependent transporters
被引 5,536Michael M. Gottesman, Tito Fojo, Susan Elaine Bates · Nature reviews. Cancer · 2002
此处列出前 3 条
引用本文 17
Rational Design of Type‐I Photodynamic Agents
被引 104Kun‐Xu Teng, Li‐Ya Niu, Jiahui Li · Angewandte Chemie International Edition · 2025
Ruthenium(ii)–Arene Complex Triggers Immunogenic Ferroptosis for Reversing Drug Resistance
被引 31Mengdi Lv, Yue Zheng, Xiangyu Dai · Journal of Medicinal Chemistry · 2024
Engineering iridium(III) complexes for enhancing electron transfer-based photodynamic therapy
被引 14Zejing Chen, Jingjing Xue, Tingwei Zhang · Coordination Chemistry Reviews · 2026
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