研究论文
Machine learning-guided engineering of chalcone synthase enables high-selectivity phloretin biosynthesis in yeast
Minyong Li, Canyu Zhang, Hui Liang, Boyu Wu, Wenxi Yu, Guangjian Li, Yufei Cao, Wen‐Yong Lou
Yunnan University Puer University South China University of Technology
内容与影响
摘要 · 完整
Machine learning-guided engineering of chalcone synthase effectively overcomes substrate promiscuity, enabling highly selective biosynthesis of phloretin in yeast, and provides a framework for the microbial production of high-value natural products.
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学术脉络
学科主题
生物医学Plant Gene Expression Analysis
Plant biochemistry and biosynthesis · Plant-Microbe Interactions and Immunity
参考文献 50
Density functional theory study of the structure–antioxidant activity of polyphenolic deoxybenzoins
被引 176Yunsheng Xue, Youguang Zheng, Lin An · Food Chemistry · 2013
Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes
被引 52Wen‐Chung Huang, Yi-Wen Dai, Huiling Peng · International Immunopharmacology · 2015
Histolocalization and physico-chemical characterization of dihydrochalcones: Insight into the role of apple major flavonoids
被引 56Matthieu Gaucher, Thomas Dugé de Bernonville, David Lohou · Phytochemistry · 2013
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施引文献 9
Biosynthesis of high-value chorismate derivatives in Escherichia coli: Recent advances and perspectives
被引 3Xuewei Pan, Shuran Jiang, Mi Tang · Biotechnology Advances · 2025
Research Progress and Prospects of Open-Chain Flavonoid Biosynthesis
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被引 0Yan Hu, Senlin Tian, Yingjie Li · Composites Science and Technology · 2026
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