Perspectives on 1,4-Benzodioxins, 1,4-Benzoxazines and their 2,3-Dihydro Derivatives

The origin and growth of the chemistry of 1,4-benzodioxins, 1,4-benzoxazines and their 2,3-dihydro derivatives are briefly described. This class of compounds has attracted special ­attention due to their natural occurrence and important biological activities. The structural scaffolds of these heterocycles serve as building blocks in various useful syntheses. The introduction of ­palladium-catalyzed reactions has added a new dimension to this field by making the synthesis more convenient and general. The purpose of this account is to facilitate and revitalize interest in this field within the synthetic community.