研究论文
In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus
Qian Wang, Ze Xiu Xiao, Xu Zheng, Guihong Wang, Linlin Yang, Lina Shi, Nan Xiang, Xingbing Wang 等 11 位
University of Science and Technology of China Anqing City Hospital Anhui University of Science and Technology Friedrich-Alexander-Universität Erlangen-Nürnberg
来源New England Journal of Medicine
年份2025
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摘要与影响
摘要 · 完整
In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects.
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学术脉络
学科主题
生物医学Systemic Lupus Erythematosus Research
CAR-T cell therapy research · T-cell and B-cell Immunology
参考文献 6
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被引 1,353Joel G. Rurik, István Tombácz, Amir Yadegari · Science · 2022
CAR T Cells Produced in vivo to Treat Cardiac Injury
被引 920Joel G. Rurik, István Tombácz, Amir Yadegari · HAL (Le Centre pour la Communication Scientifique Directe) · 2023
CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up
被引 1,095Fabian Müller, Jule Taubmann, Laura Bucci · New England Journal of Medicine · 2024
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引用本文 157
In vivo chimeric antigen receptor (CAR)-T cell therapy
被引 127Adrian Bot, Andrew M. Scharenberg, Kevin M. Friedman · Nature Reviews Drug Discovery · 2025
Engineered natural killer cells for cancer therapy
被引 55Alexander Biederstädt, Katayoun Rezvani · Cancer Cell · 2025
BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial
被引 29Tuan Vu, Hacer Durmuş, Michael H. Rivner · Nature Medicine · 2026
按被引量排序，此处列出前 3 条