研究论文
Targeting Therapeutic Oligonucleotides
Arthur A. Levin
Mandala Biosciences (United States)
来源New England Journal of Medicine
年份2017
内容与影响
摘要 · 完整
Two recent studies test whether oligonucleotide drugs that are tailored to target different cell types — the hepatocyte and the myocyte and cardiomyocyte — actually target those cell types.
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学术脉络
学科主题
生物医学RNA Interference and Gene Delivery
Advanced biosensing and bioanalysis techniques · DNA and Nucleic Acid Chemistry
参考文献 8
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
被引 2,493Mark E. Davis, Jonathan E. Zuckerman, Chung Hang Jonathan Choi · Nature · 2010
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice
被引 607Thazha P. Prakash, Mark J. Graham, Jinghua Yu · Nucleic Acids Research · 2014
Multivalent <i>N</i>-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
被引 1,097Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan · Journal of the American Chemical Society · 2014
此处列出前 3 条
施引文献 34
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
被引 1,601Kausik K. Ray, R. Scott Wright, David Kallend · New England Journal of Medicine · 2020
Chemistry, structure and function of approved oligonucleotide therapeutics
被引 810Martin Egli, Muthiah Manoharan · Nucleic Acids Research · 2023
Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting
被引 181Anas Ahmad, Farheen Khan, Rakesh Kumar Mishra · Journal of Medicinal Chemistry · 2019
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