Network pharmacology research and experimental verification of dietary flavonoid fisetin in treating myocardial hypertrophy

In this study, network pharmacology was developed to study the mechanism of fisetin in the treatment of myocardial hypertrophy. A total of 41 common targets were obtained through multi-database screening, and the core targets were determined by PPI network analysis. KEGG enrichment suggested that the effects of fisetin were mainly related to PI3K-AKT and apoptotic pathways. Western blot experiments confirmed that fisetin inhibited endoplasmic reticulum stress and apoptosis by regulating the expression of PI3K, AKT, GRP78, CHOP and Bax proteins. Our results provide promising guidance for the subsequent clinical application of fisetin in the treatment of myocardial hypertrophy.