Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors
Reiner Strick, Pamela L. Strissel, Stephen B. Baylin, Katherine Bakshian Chiappinelli
Friedrich-Alexander-Universität Erlangen-Nürnberg Universitätsklinikum Erlangen Johns Hopkins University Johns Hopkins Hospital
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摘要与影响
Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.
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生物医学Epigenetics and DNA Methylation
Immunotherapy and Immune Responses · Cancer Immunotherapy and Biomarkers
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