Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling sequelae of numerous chemotherapeutic agents used in the treatment of cancers. When it occurs during treatment, it may lead to early cessation of chemotherapy and thus increased risk of cancer mortality. As a chronic illness, it can have serious effects on independence and quality of life for years after chemotherapy has ended. While the incidence of acute neuropathic pain during treatment can approach 90%, more than half of patients may experience prolonged neuropathy symptoms following cessation of therapy. Prior to attributing neuropathic pain to chemotherapy, clinicians should be vigilant to rule out other common causes. Pharmacologic and nonpharmacologic modalities exist for both the prevention and treatment of CIPN, and judicious monitoring must be conducted.