Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
Chiara Di Malta, Diletta Siciliano, Alessia Calcagnì, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea Eastes, Oliver B. Davis 等 21 位
Telethon Institute Of Genetics And Medicine European Institute of Oncology Baylor College of Medicine University of California, San Francisco
阅读操作
确认中在文库中上传 PDF 后可生成中文音频讲解。
摘要与影响
genes in cells and tissues from patients and murine models of renal cell carcinoma, pancreatic ductal adenocarcinoma, and melanoma triggered RagD-mediated mTORC1 induction, resulting in cell hyperproliferation and cancer growth. Thus, this transcriptional regulatory mechanism enables cellular adaptation to nutrient availability and supports the energy-demanding metabolism of cancer cells.
逐年被引趋势
关键指标
同类平均 = 1
同领域 · 同年份 · 同类型
Google Scholar 与 OpenAlex 的被引统计范围不同，数值存在差异属正常。
AI 辅助阅读
依据：摘要
可就本文提问；依据不足时会说明。
学术脉络
学科主题
生物医学PI3K/AKT/mTOR signaling in cancer
Metabolism, Diabetes, and Cancer · Cancer, Hypoxia, and Metabolism