研究论文
Key Tertiary Interactions in FMN Riboswitch Aptamers Required for Ligand Binding
Ambadas B. Rode, Tamaki Endoh, Naoki Sugimoto
Konan University
来源Bulletin of the Chemical Society of Japan
年份2015
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摘要 · 完整
The key tertiary interactions in the riboswitch aptamer that are critical for flavin mononucleotide binding were identified by structure-guided mutations. Binding affinity was reduced significantly (more than 16-fold) after disruption of non-canonical G·G base pair and enhanced moderately (up to 2.1-fold) after mutation in the base triple or T-loop like motif.
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参考文献 19
A general method for selection of riboflavin-overproducing food grade micro-organisms
被引 142Catherine M. Burgess, Eddy J. Smid, Ger Rutten · Microbial Cell Factories · 2006
Multiple conformations of SAM-II riboswitch detected with SAXS and NMR spectroscopy
被引 74Bin Chen, Xiaobing Zuo, Yun-Xing Wang · Nucleic Acids Research · 2011
Comparative Sequence and Structure Analysis Reveals the Conservation and Diversity of Nucleotide Positions and Their Associated Tertiary Interactions in the Riboswitches
被引 19Sri Devan Appasamy, Effirul Ikhwan Ramlan, Mohd Firdaus‐Raih · PLoS ONE · 2013
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引用本文 11
tRNA Shifts the G‐quadruplex–Hairpin Conformational Equilibrium in RNA towards the Hairpin Conformer
被引 33Ambadas B. Rode, Tamaki Endoh, Naoki Sugimoto · Angewandte Chemie International Edition · 2016
Chemical Biology of Double Helical and Non-Double Helical Nucleic Acids: “To B or Not To B, That Is the Question”
被引 28Naoki Sugimoto, Tamaki Endoh, Shuntaro Takahashi · Bulletin of the Chemical Society of Japan · 2021
Crowding Shifts the FMN Recognition Mechanism of Riboswitch Aptamer from Conformational Selection to Induced Fit
被引 28Ambadas B. Rode, Tamaki Endoh, Naoki Sugimoto · Angewandte Chemie International Edition · 2018
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