Therapeutic Effectiveness of Hernandezine in Medicine for the Treatment of Cancer and other Human Complications: A Biologically active Bisbenzylisoquinoline Alkaloid from Nature

P lant derived herbal products have an important role in the human healthy lifestyle due to their vast therapeutic potential in medicine against different kinds of human disorders and complications.Herbs and their derived byproducts, including pure phytochemicals have been utilized as medi-cines and drug lead molecules in the healthcare system for the development of better drugs against human disorders and complications.The World Health Organization (WHO) also recognized the importance of herbal products in medicine throughout the world.Pure phytochemicals such as as-Alkaloids are widely distributed in nature, especially in plants, animals, microorganisms and marine organisms.Hernandezine is a biologically active bisbenzylisoquinoline class alkaloid found to be present in different species of Thalictrum.The present review describes the biological potential and therapeutic effectiveness of hernandezine in medicine for the treatment of human disorders and associated secondary complications.The aim of the present paper is to collect all the scientific data of hernandezine from different scientific databases, including Scopus, Science Direct, Google, PubMed and Google Scholar and analyzed in the present paper in order to know the therapeutic potential of hernandezine in medicine.Present paper mainly focus on the pharmacological activities of hernandezine, however, pharmacokinetic data of hernandezine has also been described in the present review.Present review scientific data revealed the biological significance of hernandezine in medicine for the treatment of human disorders and associated secondary complications.Present review scientific data describe the medicinal importance of hernandezine through its therapeutic effectiveness on pancreatic cancer, hepatocellular carcinoma, type 2 diabetes, melanoma, colon cancer, glioma cells, acetylcholine receptor, hair cells, Ca 2+ release, multidrug-resistance, permeabilization and TNF-α production.However, immunosuppressive potential and pharmacokinetic parameters of hernandezine were also described in the present work in order to know the different molecular mechanism of hernandezine.Present review also described the different molecular mechanisms of hernandezine.However, detailed preclinical and clinical scientific investigation is utmost important in the scientific fields in order to claim its therapeutic application in human disorders and associated secondary complications.