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Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease
Scott J. Gratz, Alexander M Cummings, Jennifer N Nguyen, Danielle C. Hamm, Laura K Donohue, Melissa M. Harrison, Jill Wildonger, Kate M. O’Connor-Giles
University of Wisconsin–Madison
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摘要与影响
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We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila genome and report that Cas9-mediated genomic modifications are efficiently transmitted through the germline. This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila.
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学科主题
生物医学CRISPR and Genetic Engineering
RNA regulation and disease · Animal Genetics and Reproduction
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