A STUDY ON THE SOLUBILITY AND STABILITY OF ETHINYL OESTRADIOL

Atrial was made to prepare solutions of ethinyl oestradiol by series of selected surfactants. It was found that the cationic surfactant was the best solubilizer for this hormone followed by the anionic then the non-ionic ones. The solubilized systems were further investigated for their stability under different storage conditions. It was noticed that the solutions prepared by non-ionic surfactants gave rise to the most stable preparation for this hormone, especially in the presence of antioxidants and preservatives. Storage of this preparation in amber coloured ampoules at 5° was also desirable, as it can keep its potency for a period up to 6 months.