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A Novel Method for Floxed Gene Manipulation Using TAT-Cre Recombinase in Ex Vivo Precision-Cut Lung Slices (PCLS)
Sek‐Shir Cheong, Tiago Cunha Luis, Matthew David Hind, Charlotte H. Dean
Imperial College London Royal Brompton & Harefield NHS Foundation Trust National Institute for Health and Care Research
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摘要 · 完整
. • With optimisation, this method can be applied to precision-cut tissue slices of other organs.
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学科主题
生物医学CRISPR and Genetic Engineering
RNA Interference and Gene Delivery · Animal Genetics and Reproduction
参考文献 7
An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices
被引 263Hani N. Alsafadi, Claudia A. Staab-Weijnitz, Mareike Lehmann · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2017
Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours
被引 25Katja Maria Närhi, Ashwini Sakrepatna Nagaraj, Elina Parri · The Journal of Pathology · 2018
Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour
被引 104Khondoker M. Akram, Laura L. Yates, Róisín Mongey · Nature Communications · 2019
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引用本文 3
Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report
被引 41Mareike Lehmann, Ramaswamy Krishnan, Jennifer M. S. Sucre · American Journal of Respiratory Cell and Molecular Biology · 2024
Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics
被引 0Rashid A. Aldahhan, Amal Ahmed El-Sheikh · Translational Research in Anatomy · 2025
Development of label-free light-controlled gene expression technologies using mid-IR and terahertz light
被引 0Hirohito Yamazaki, Ryusei Sugawara, Yurito Takayama · Frontiers in Bioengineering and Biotechnology · 2024
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