Simultaneous Determination of Acetylsalicylic Acid, Paracetamol and Ascorbic Acid in Effervescent Tablet by Different Chemometric Methods

The spectrophotometric identification of acetylsalicylic acid, paracetamol, and ascorbic acid in the effervescent tablet.wasinvestigated in this work.For acetylsalicylic acid, paracetamol, and ascorbic acid, chemometric analysis of the effervescent tablet.hasproved successful.The spectrophotometric analysis of the effervescent tablet was done using the multivariate calibration methods: The multiple linear regression (UV-MLR) and The classical least squares approach (UV-CLS).Two spectrophotometric-chemometric methods were presented for the simultaneous prediction of the effervescent tablet in prepared mixes and pharmaceutical tablets without prior separation.The artificial mixtures were initially made with acetylsalicylic acid, paracetamol, and ascorbic acid, and the absorbance values were calculated using spectrophotometry.In the second stage, the amounts of common cold infection medications in the pharmaceutical tablets were calculated.Each medication's calibration curves are linear in the synthetic mix's concentration range.High recoveries and small standard deviations were determined, and the two techniques were evaluated for accuracy and repeatability.In the UV-MLR method, the SEC, PRESS, LOD and LOQ values were respectively; 0.032, 0.0040, 0.085, 0.283 for acetylsalicylic acid, 0.012, 0.0052, 0.091, 0.303 for paracetamol, 0,035, 0,0065, 0,084, 0,280 for ascorbic acid.In the UV-CLS method, the SEC, PRESS, LOD and LOQ values were respectively; 0.042, 0.0038, 0.057, 0.190 for acetylsalicylic acid, 0.025, 0.0057, 0.092, 0.307 for paracetamol, 0.054, 0.0058, 0.056, 0.187 for ascorbic acid.The applied chemometric approaches give quick, simple, and reliable findings.The proposed methods have been successfully used to identify the active compounds (acetylsalicylic acid, paracetamol, and ascorbic acid) in the effervescent tablet because they are very sensitive and accurate.