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Commentary: Programmable base editing of A·T to G·C in genomic DNA without DNA cleavage
Ianis G. Matsoukas
University of Greater Manchester
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摘要与影响
摘要 · 完整
An article recently published in Nature (Gaudelli et al., 2017) reports an approach of altering DNA sequences without cleaving the DNA strands.This method of gene editing, exploits a modified version of the CRISPR-Cas9 system and an RNA-based deamination enzyme.
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学术脉络
学科主题
生物医学CRISPR and Genetic Engineering
RNA regulation and disease · DNA and Nucleic Acid Chemistry
参考文献 39
The Mechanism of Human Nonhomologous DNA End Joining
被引 732Michael R. Lieber · Journal of Biological Chemistry · 2007
Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing
被引 441Mark R. Macbeth, Heidi Schubert, Andrew P. VanDemark · Science · 2005
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
被引 2,752Jens Boch, Heidi Scholze, Sebastian Schornack · Science · 2009
此处列出前 3 条
引用本文 29
An EU Perspective on Biosafety Considerations for Plants Developed by Genome Editing and Other New Genetic Modification Techniques (nGMs)
被引 100Michael F. Eckerstorfer, Marion Dolezel, Andreas Heissenberger · Frontiers in Bioengineering and Biotechnology · 2019
Principles of and strategies for germline gene therapy
被引 73Don P. Wolf, Paul A. Mitalipov, Shoukhrat M. Mitalipov · Nature Medicine · 2019
Prime Editing: Genome Editing for Rare Genetic Diseases Without Double-Strand Breaks or Donor DNA
被引 71Ianis G. Matsoukas · Frontiers in Genetics · 2020
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