The Role of Klotho in Pediatric Diseases and Aging

Klotho seems to play an important role in different pediatric diseases.We focus on the role of Klotho and different pediatric diseases.Any correlations were found in chronic kidney disease, sickle cell disease, depression in childhood, Non-Alcoholic Fatty Liver Disease (NAFLD), surgery for Congenital Heart Defects (CHD), beta thalassemia major, diabetic pediatric nephropathy, pediatric hematopoietic stem cell development and erythropoiesis, sevoflurane induced pediatric neuronal injury and nevertheless, aging in children.Klotho plays a crucial role in aging processes, even in children.Especially in children with Hutchinson-Gilford syndrome, in which the children undergo a premature aging process, Klotho could play a crucial role.Investigating this would be a desirable approach to evaluate more precisely the role of Klotho on the child organism.