[Sirtuins as geroprotectors and epigenetic regulators of cell cycle.]
Y I Belova, V N Khabarov, T V Kvetnaya
St. Petersburg Institute of Bioregulation and Gerontology Saint-Petersburg Research Institute of Phthisiopulmonology Saint Petersburg State Pediatric Medical University Hyaluronan Research Institute
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Epigenetic mechanisms, including DNA methylation, histone modification, and regulation by non-coding RNAs, play a key role in cell cycle and cell senescence control. A special place among epigenetic regulators is occupied by sirtuins, NAD⁺-dependent deacetylases involved in maintaining genomic stability, DNA repair, and transcription regulation. In this article, we consider the role of sirtuins (SIRT1, SIRT2, SIRT6, SIRT7) as integrators of epigenetic signals affecting the passage of the cell cycle and cell aging.
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