胍基荧光碳点的制备及其抗菌性能

In this paper， we report a fluorescent carbon dot with a guanidine group on the surface， which has excel• lent luminescence properties and biosafety， and can effectively inhibit Escherichia coli (E.coli) and Staphylococcus aureus (S. aureus).We synthesized biguanide carbon dots (BHCDs) with fluorescent properties in both solid and liquid states by hydrothermal method using biguanide hydrochloride， dithiodibenzoic acid and acetic acid as raw ma• terials.High-resolution transmission electron microscopy showed that the average grain of the carbon dot was 2. 24 nm， and its emission wavelength was 420 nm， and it shifted backward with the increase of excitation wavelength.Ac• cording to XPS and FTIR spectra， it is inferred that there is a guanidine group on the surface of BHCDs.Biological imaging experiments showed that BHCDs fluoresced blue when they entered zebrafish and could be completely metab • olized out of the body within 96 h， which showed that BHCDs had good biological safety in combination with other toxicological experiments.BHCDs can effectively inhibit the growth of E. coli and S. aureus.In the process of 文章编号： 1000-7032(2025)01-0174-11 收稿日期： 2024•10•14； 修订日期： 2024•10•26 基金项目： 科技部变革性技术关键科学问题重点研发计划(2019YFA0705202)； 国家自然科学基金(62274027)； 松山湖材料实验室 开放课题重点项目(2023SLABFK03)