Flow Cytometry in Cell-Based Pharmacokinetics or Cellular Kinetics in Adoptive Cell Therapy

Pharmacokinetics (PK) defines the disposition of a drug in the body based primarily on measurements in fluids or tissues by various bioanalytical methods during the drug development. Most bioanalytical methods utilize ligandbinding or LC-MS technology, and the assays are validated and applied following the guidelines from various regulatory agencies in their countries (e.g., US FDA, EMEA or Health Canada) These bioanalytical method guidelines focus on the PK of traditional drug compounds; small molecules and large biomolecules.