Nasopharyngeal Cancer Stem Cells Drive Immune Paralysis via the MIF, CD96, and CD99 Axis Despite Intact Antigen Presentation

Nasopharyngeal carcinoma (NPC) is characterized by significant intratumoral heterogeneity and a propensity for recurrence driven by therapy-resistant Cancer Stem Cells (CSCs). While the genomic landscape of adult NPC is increasingly understood, the cellular architecture of paediatric NPC and its distinct stem cell hierarchies remain largely unexplored. To overcome the limitations of short-read sequencing in resolving complex transcriptomes, we performed high-resolution, long-read single-cell RNA