Low Dose CT Image Denoising: A Comparative Study of Deep Learning Models and Training Strategies

Low-dose computed tomography (LDCT) denoising is an important topic in CT image research. Compared with normal-dose CT images, LDCT can reduce the radiation dose of X-rays, decreasing the radiation burden on the human body, which is beneficial to human health. However, quantum noise caused by low-dose rays will reduce the quality of CT images, thereby decreasing the accuracy of clinical diagnosis. In recent years, deep learning-based denoising methods have shown promising advantages in this field. Researchers have proposed some optimized models for low-dose CT image denoising. These methods have enhanced the application of low-dose CT image denoising from different aspects. From the perspective of experimental research, this paper investigates and evaluates some top deep learning models proposed in the field of low-dose image denoising in recent years, with the aim of determining the best models and training strategies for this task. We conducted experiments on seven deep learning models (REDCNN, EDCNN, QAE, OCTNet, UNet, WGAN, CTformer) on the AAPM dataset and the Piglet dataset. Our research shows that UNet has the best denoising effect among the models, obtaining PSNR = 33.06 (AAPM dataset) and PSNR = 31.21 (Piglet dataset), and good generalization capacity is also observed. However, UNet has a large number of parameters, and the time it takes to process an image is about 8 ms, while EDCNN takes about 4.8 ms to process an image, and its average PSNR is ranked second after UNet. EDCNN strikes a balance between denoising performance and processing efficiency, making it ideal for low-dose CT image denoising tasks.