Scaffolds for Tissue Engineering Via Thermally Induced Phase Separation

matrix (ECM) in terms of the structure, chemical composition, and mechanical properties.The scaffolds that play a key role in tissue engineering require certain characteristics as high interconnected porosity in order to allow the vascularization process, appropriate distribution and pore size according to the tissue to be regenerated, sufficient initial mechanical strength, biodegradability and biocompatibility.These materials have to provide a suitable environment for the adherence, proliferation and cell differentiation and guide tissue development.Although, there are many approaches to obtain scaffolds to fulfill all requirements, it still represents a big challenge, because it is not clear what defines an ideal scaffold/cell construct, even for a specific tissue type due to its the complexity that include material composition, porous architecture like type, size and interconnection of the pores, structural mechanics, surface properties, degradation properties, products of degradation, biocomopatibility, kinetic of scaffold degradation, etc.This complexity can be appreciated schematically in figure 2 (Hutmacher et al., 2008).