Abnormal amygdala resting-state functional connectivity in patients with anxiety disorders: A coordinate-based imaging meta-analysis.

Motivation: It is necessary to clarify the neurobiological mechanisms of anxiety disorders (ADs) to provide a unique biomarker for diagnosing ADs, facilitating accurate clinical diagnosis and targeted therapeutic interventions. Goal(s): The primary objective is to elucidate the specific abnormalities in individuals with ADs' amygdala-based whole-brain connectivity. Approach: The coordinate-based meta-analysis was conducted to find amygdala resting-state functional connectivity in patients with ADs. Furthermore, subgroup analysis was performed to explore potential functional lateralization. Results: Distinct functional connectivity abnormalities were found in ADs, which provides a reference for diagnosing ADs. Impact: These findings not only enhance our understanding of the underlying pathophysiological mechanisms in ADs but also may be valuable for the prevention, diagnosis and intervention of ADs.