Research Progress on the Synthesis of Nitrogen-Containing Compounds with Cyanamide as a Building Block

Nitrogen-containing compounds are widely found in many natural products and have a wide range of pharmacological and physiological activities.Furthermore, they have comprehensive applications in medicine and pesticide fields, industry and multi-functional materials.Great advances in the synthesis of these compounds have been sprung up, a diversity of synthetic methods of them via cyanamide (NH2-CN) as raw material were exploited in recent years.The research progress on the synthesis of nitrogen-containing compounds through cyanamide as a building block is introduced comprehensively.Moreover, their characteristics, rules, advantages and disadvantages are summarized and discussed for the development of new synthetic methodologies and reactions of nitrogen-containing compounds.Keywords cyanamide; natural origin; nitrogen-containing compound; pharmaceutical 含氮化合物具有生物活性和药物活性(图 1), 如抗 肿瘤药性 [1] 、抗菌药性 [2] 、杀虫活性及杀菌活性 [3] 、抗组 织蛋白酶活性 [4] 和抗磷酸二酯酶活性 [5] .因此, 它被广 泛地应用于医药和农药等领域.此外, 它也被作为重要 的染料成分和有机合成中间体.氨基氰(NH 2 -CN)是一种带有氨基和氰基双官能团 的重要精细化工原料, 可用于各种官能团转化.比如氰 胺转化为碳二亚胺 [6] 、双氰胺 [7] 、胍 [8] 、硫脲 [9] 和尿素 [10]