Sustained-release oxymatrine hydrogel enhances the survival of transplanted placental mesenchymal stem cells and promotes wound healing in diabetic mice
Lu Liu, Xiaodan Liu, Ting Liu, Haibin Ma, Dongmei Chen, Shudan Liu
First Affiliated Hospital of Xi'an Jiaotong University Ningxia Medical University Ningxia Medical University General Hospital
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M2 macrophage polarization, and activating Nrf2/HO-1-mediated antioxidant defenses, thereby protecting PMSCs from oxidative stress-induced apoptosis. Collectively, these findings demonstrate that OMT-loaded HAMA hydrogel synergizes with PMSCs to reconstruct a pro-regenerative microenvironment, offering a promising cell, material, and small-molecule combinatorial strategy for the effective treatment of chronic diabetic wounds.
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生物医学Wound Healing and Treatments
Tissue Engineering and Regenerative Medicine · Hydrogels: synthesis, properties, applications